Atherosclerosis begins with an inflammatory lesion of the blood vessel. Immune cells are attracted to the site of the lesion. They accumulate and form fibrous deposits of lipid-laden cells: atheromatous plaques. With time atheromatous plaques can obstruct the blood vessels; they can also detach and cause strokes or embolisms.
Atherosclerosis is favored by our modern lifestyles: stress, smoking, high fat diet. Obesity, high blood pressure and diabetes are also significant risk factors. A chronic inflammatory state favours atherosclerosis. Inflammation contributes to activation of immune cells and plaque formation. It also increases the risk of plaque rupture and thrombosis. See also FAQ: What are the risk factors for atherosclerosis
Our modern lifestyles: stress, smoking, high fat diet: can predispose us to atherosclerosis. Obesity, high blood pressure, diabetes and a chronic inflammatory state are also significant risk factors. Inflammation contributes to activation of immune cells and plaque formation. It also increases the risk of plaque rupture and thrombosis.
It is usually considered that high levels of "bad cholesterol" (LDL) favour atherosclerosis. However, it is not the LDL itself which causes problems but rather its oxidized form (oxLDL). Oxidized LDL reacts with the blood vessels, causing inflammation; it accumulates in the cells which will form the core of atheromatous plaques. Oxidation of LDL can have several origins; a decrease in antioxidant capacity (especially due to aging), smoking...High levels of homocysteine (due to genetic predispositions or vitamin B deficiencies) are also linked to inflammation and increases oxidation of LDL. Reducing cholesterol levels is a strategy to prevent atherosclerosis; it will be much more effective when combined with an approach which allows reduction of inflammation and oxidative stress.
Lactobacillus fermentum ME-3 is a strain of lactic acid bacteria. It has the capacity to accumulate and regenerate glutathione, an essential cellular antioxidant. Clinical studies have shown that consumption of ME-3 leads to a reduction of inflammation and blood lipid oxidation (oxLDL).
ARTERY DEFENCE acts therefore at three levels: maintenance of cholersterol levels, protection against oxidative stress, contribution to normal homocysteine metabolism.
Lactobacillus fementum ME-3 is a lactic acid bacteria. The strain was isolated by a team of microbiologists from the University of Tartu Estonia. Several clinical studies have shown its positive effects on inflammatory markers, blood lipid levels and parameters linked to oxidative stress.
PATENTED STRAIN Patented in Russia, Europe, USA; deposited as DSMZ14241. EXCELLENT PROBIOTIC PROPERTIES Strong resistance to gastro-intestinal environment (bile acids, low pH), lectin profile suitable for adhesion to gut epithelium.